They don’t look like much. They can be anything from
microscopic in size to huge sea kelps and seaweeds, but they’ve never
commanded much attention from the general public. And yet algae could be
the answer to some of the most pressing problems facing mankind today.
Algae grow quickly and abundantly in all kinds of water, and contain
high levels of antioxidants, omega-3 oil, carbohydrates, sugars and
proteins, making them unusually nutrient-rich. They can be used for
renewable fuel, animal feed, cosmetics, fertilizer, drug delivery,
nutraceuticals, water purification, bioplastic, lubricants and even
human food. It’s an impressive list.
Indeed, you’ll already find algae at the heart of many food products
from baby formula to ice-cream, providing texture, stabilizing features
and important nutrients for health; as well as in deluxe skin-care products and dietary supplements.
It’s no surprise, then, that billions of dollars have been invested
in the research of algae-based technologies, and Israel, as the startup
nation, is at the forefront of much of the leading innovation emerging
in this field.
“Israel is considered an empire in microalgae technologies,” says
Yoni Sharon, an executive at UniVerve, one of the Israeli companies
revolutionizing this field. “Both because of Israeli academic support
and Israelis’ innovative thinking and problem-solving attitude, Israel
has been a leader in microalgae technologies for the last two or three
decades.”
“We see enormous interest in the algae space because of its ability
to derive ingredients relevant to food, supplements and cosmetics, the
heart of our business,” says Yoni Glickman, president of natural product
solutions at Frutarom Industries of Haifa, one of the world’s 10 largest flavors and specialty natural ingredients companies.
“We are always asking how we can bring more natural products into the
food chain as the world moves away from synthetic ingredients, and we
think algae provides an incredible platform to deliver that,” Glickman
tells ISRAEL21c.
Here are seven of the Israeli companies betting on algae for 2016 and beyond.
1. TransAlgae in
Rehovot was founded in 2008 during the worldwide race to make
affordable biodiesel fuel from algae. After that bubble burst, the
company found a novel high-value alternative for its proprietary
technology for genetically engineering algae: delivering protein-based
drugs and other biomolecules orally rather than by injection.
Though it could one day apply in human medicine, the technology for
now is aimed at orally delivering biomolecules to animals, such as fish
and chicken. Injecting their animals costs farmers quite a lot in terms
of time, money and manpower. TransAlgae’s technology changes algae into a
platform that produces and orally delivers the medication safely to the
bloodstream, says COO Doron Eisenstat.
Algae grown at TransAlgae’s beta production site near Latrun are
mainly for R&D purposes so far, but Eisenstat expects the algae to
go on the market this year. Once commercial regulation and registration
processes are completed, enhanced algae will also enter specific
markets.
TransAlgae’s lead product accelerates growth of young fish in
aquaculture farms. Down the line, the privately held company hopes to
add products including fish and poultry vaccines and crop-protection
molecules based on its unique platform.
2. Algatechnologies
is a world leader in the production and supply of AstaPure brand
astaxanthin, a powerful antioxidant sourced from the red microalga
Haematococcus pluvialis. Astaxanthin has been proven beneficial to
vision, the immune system and skin texture, while protecting against the
effects of radiation and aging.
AstaPure softgel and hardshell capsules, topical creams, emulsions,
drink mixes and suspensions — which just received verification from the
Non-GMO Project — are sold to manufacturers of dietary supplements,
cosmetics and functional foods and beverages in 30 countries. Most
customers are in Japan and the United States.
lgatechnologies, in Israel’s Arava desert, is a pioneer in producing astaxanthin from red microalgae. Photo courtesy
Founded in 1998 at Kibbutz Ketura and acquired by the British firm
Grovepoint in 2013, Algatechnologies developed a way to mass-produce
microalgae in Israel’s hot Arava desert near Eilat. Algatech was one of
the first in the business.
“We doubled production two years ago and we are continuously
expanding and spending on R&D to find additional microalgae with
active ingredients,” says Chairman Ed Hofland, who also is involved in
other environmental enterprises at Ketura including Arava Power for
solar energy.
“There is a lot of buzz in Israel about the microalgae business, and I think it’s driven by our success,” adds Hofland.
3. Qualitas Health,
founded in Jerusalem in 2012, is the world’s only algae company with an
FDA-approved omega-3 product, produced from algae grown sustainably on a
250-dunam (62-acre) production capacity in Texas.
Qualitas Health makes the world’s only FDA-approved omega-3 product from algae. Photo: courtesy\
“Qualitas Health took algae from boutique production into something
we call algaculture, at a lower cost and on a huge scale,” CTO Isaac
Berzin tells ISRAEL21c.
Most people get their omega-3 from fish oil, but the fish get it from
algae. Cutting out the fish “middleman” makes sense — if the price is
comparable and the nutrient is at least as well absorbed by humans. This
is Qualitas’ unique achievement, says Berzin.
The company’s Almega PL is sold through distributors in the United States and will soon be available in other countries.
“When you grow algae for omega-3, that is only a small percentage of
total biomass,” adds Berzin. The rest of the biomass consists of an
easily absorbed protein with a complete amino-acid profile.
“The world is desperate for alternative protein sources and our algae
need no freshwater and no fertile land usage, so it is an extremely
sustainable platform for producing protein. We are developing the
product with several large customers.”
Berzin, whose work in algae biotechnology placed him on TIME
Magazine’s Top 100 people in the world for 2008, founded the first
company in the world developing algal biofuels and designed algae
cultivation systems for NASA.
4. Aquanos won
the Cleanvest Cup for best innovative company at the 2015 Watec Israel
conference for its energy-efficient wastewater-filtering system using
microalgae-fueled oxygen. The company’s CEO, Udi Leshem, won a ticket to
present at the first China-Israel Technology Innovation & Investment Summit held in Beijing in early January.
Founded in 2011 in Shoshanat HaAmakim north of Netanya, Aquanos is
installing its unique wastewater treatment systems across Africa, Asia,
North America and Israel. Its system uses up to 90 percent less energy
than do conventional aerobic wastewater treatment plants, and produces
biogas as a byproduct. The microalgae can then be harvested to make
other products such as fertilizers and bioplastics.
In May last year, Aquanos was featured at a Global Entrepreneurs
event at the White House, and in December 2014, Aquanos was one of four
winners in the Tel Aviv Challenge Cup, a competition organized by
US-based accelerator 1776.
5. UniVerve
UniVerve, founded in 2009 in Tel Aviv, is establishing microalgae farms based on its proprietary technology.
“UniVerve sees microalgae biomass as a feedstock for many existing
and future industries such as food, feed and fuel,” says Yoni Sharon,
the company’s vice president for business development, who has a PhD in
plant eco-physiology.
Its first commercial farm, based on Kibbutz Neve Eitan in the Beit
She’an Valley not far from the Sea of Galilee, is producing omega-3 rich
biomass for the food-supplements -and feed industries. The farm is also
meant to serve as a training center for clients wishing to establish
algae farms overseas.
Sharon says that UniVerve intends to revolutionize the microalgae
production industry. “Our vision is that our technology will result in
feedstocks, biomass and products that are much more cost-effective and
affordable.”
“UniVerve recently initiated negotiations with Chinese partners to
establish a subsidiary and new projects in China,” he adds. “We are
looking for business partners to invest in new projects and help us
further develop our product portfolio. The potential for the biomass is
enormous, so we are taking a wide perspective.”
Univerve’s microalgae farm under construction in the Beit She’an Valley. Photo: courtesy
6. Frutarom Industries
cultivates algae as the source for a variety of active ingredients,
based on technology licensed from Ben-Gurion University of the Negev in
2003.
“We have a significant growing facility in Moshav Gilat in southern
Israel for the microalga Porphyridium, used as an anti-inflammatory
cosmetic ingredient in many major high-end brands across the world,”
says Yoni Glickman, president of natural product solutions at Frutarom.
Because the well-established company has thousands of customers
across the world, it has the advantage of being able to move into
algae-seeking markets quickly and easily, he adds. “We can take those
technologies and put them right in our ecosystem to fill demands from
global customers.”
7. Algalo Industries of
Kibbutz Ein Hamifratz has developed a unique method for efficient
cultivation, harvesting and processing of a wide variety of microalgae.
Frutarom recently invested NIS10 million (about $2.6 million) in
Algalo and will build a modern biotech facility there to produce
microalgae for the food, dietary and clinical nutrition supplements and
cosmetics industries. Frutarom will have exclusive global rights to
market the Algalo products.
“This new investment represents a major move to the world of food and
food supplements,” says Frutarom’s Glickman. “We bought 50 percent of
Algalo to help our ability to grow algae more effectively and get the
maximum harvest per unit so we can further develop new products. A lot
of the growth in the algae market is not as good as it could be because
the growing platforms are not ready for mass applications. This will
provide a robust and economical platform as the world market expands
dramatically.”