Experimental Drug Kills Malaria Parasite In 2 Days?

by Lisa Winter

Malaria kills over 550,000 children each year; nearly one every minute. The disease is transmitted through four species of Plasmodium parasite that travels through a mosquito vector. Though concerted efforts have cut the number of malaria cases in half since 2001, there is still a lot of work to be done to achieve complete eradication. A new molecule called (+)-SJ733 has been shown to effectively kill the malaria parasite in mice within 48 hours. R. Kiplin Guy of St. Jude Children’s Research Hospital is senior author on the paper, which has been published in the Proceedings of the National Academy of Sciences.

Using a mouse model, a single dose of SJ733 was able to eliminate 80% of the parasite within 24 hours, and bring it to undetectable levels by 48 hours. Attempts at using other drugs to combat malaria have been difficult, due to increased levels of drug resistance. However, SJ733 works quickly enough that this might not become a problem.

"Our goal is to develop an affordable, fast-acting combination therapy that cures malaria with a single dose," Guy said in a press release. "These results indicate that SJ733 and other compounds that act in a similar fashion are highly attractive additions to the global malaria eradication campaign, which would mean so much for the world's children, who are central to the mission of St. Jude.”

Previous work by St. Jude’s led to the development of SJ733. This new study identified the mechanism the compound uses to trigger the immune system and attack infected red blood cells, while leaving healthy cells unharmed. For cells infected with the parasite, SJ733 interferes with the ATP4 protein, which operates a pump that regulates cellular sodium level. 

Without a functional pump, the sodium level in the cell gets too high. Not only does the cell change shape and shrink, but it also becomes more rigid. These are normal characteristics of aging cells, which the immune system is easily able to discard. This way, the drug isn’t necessarily attacking the parasite itself, but rather using it as a marker to destroy the entire infected cell. SJ733 isn’t the only drug that operates in this way. ATP4 is also targeted by a class of drugs called spiroindolones. A spiroindolone known as NITD246 has already begun human trials with other institutions. 

"The data suggest that compounds targeting ATP4 induce physical changes in the infected red blood cells that allow the immune system or erythrocyte quality control mechanisms to recognize and rapidly eliminate infected cells," added co-author Joseph DeRisi of the University of California, San Francisco. "This rapid clearance response depends on the presence of both the parasite and the investigational drug. That is important because it leaves uninfected red blood cells, also known as erythrocytes, unharmed.”

Following the success of this study, the researchers are now going forward and planning the first human clinical trials. 

http://www.iflscience.com/health-and-medicine/experimental-drug-kills-malaria-parasite-2-days

New miracle cure for deadly Hepatitis C

A DAILY pill can cure deadly hepatitis C in months and may wipe out the disease altogether, experts say.

By Lucy Johnson

The new drug, which will be available on the NHS, has been shown to eliminate the virus in up to 98 per cent of patients.

It is estimated to affect 216,000 victims in the UK, including 85,000 diagnosed cases, and can lead to liver cancer.

Specialists say the drug Daklinza, will also stem the huge rise in cases of serious liver ­disease and cancer caused by the condition.

They have ­soared by 450 per cent in the past 15 years, from 5,500 cases in 2000, to 24,600 last year.

It still needs to be tested on certain types of hepatitis C but has proved successful on those for which it has been prescribed.

The late Body Shop founder Dame Anita Roddick suffered from the disease after she was given a contaminated blood transfusion in 1971.

Charles Gore, Hepatitis C Trust chief executive, said: “We are delighted patients will have access to this new treatment.

This takes us one step closer to making the elimination of ­hepatitis C a realistic possibility by improving both cure rates and tolerability.”

Liver specialist Dr John ­Dillon, at Ninewells Hospital, Dundee, said: “New treatment options that can cure this virus are really important.

"The launch of this treatment in the UK is another big step forward.

"Its arrival paves the way for the use of treatment regimens that are oral, much more tolerable for patients than older treatments, and offer the chance of a cure."

Unlike older therapies, which try to boost the body’s immune system, a new class of drugs, known as NS5A inhibitors, bind to a protein in the virus to stop it replicating.

One of these, ­Daklinza, is most effective in patients who have late stages of the disease, many of whom are on the transplant waiting list.

Current treatments are less effective and involve a long course of immune-boosting drugs with severe side effects including depression, anaemia and fatigue.

The new drug has few unwanted effects and is taken for three months.

Nearly all sufferers are then free of the ­disease and experts believe it could eradicate hepatitis C, within 15 years.

The launch of this treatment in the UK is another big step forward

Dr John ­Dillon

The virus is associated with tainted blood transfusions from Europe and the US before screening was introduced in 1991, plus non-­sterile needles used by ­tattooists and intravenous drug users.

One in five liver transplants in the UK, 170 a year, is due to ­hepatitis C damage.

Many ­victims do not ­realise they have it as symptoms can be silent and surface only as the disease progresses.

In 2004 Anita Roddick announced she had hepatitis C.

She had lived with the virus for more than 30 years before discovering she was contaminated after a transfusion following the birth of her son Sam.

By this time she was suffering from severe liver damage.

The new drug will become available to patients on the NHS early next year.

Some severely ill patients have been given early access under a new scheme by NHS England.

Johanna Mercier, general manager of Bristol-Myers Squibb, which developed the drug, said: “We are committed to imp-roving the quality of life of patients living with hepatitis C and paving the way to cure this chronic and ­devastating ­condition.”

http://www.express.co.uk/news/uk/510655/New-miracle-cure-for-deadly-Hepatitis-C

This Amazing Oriental Tea Can Cure More Than 50 Health Conditions And Detox The Body

We suggest that you prepare this ancient folk super-tea recipe that cures more than 50 health conditions, and it contains oriental spices such as: turmeric, cloves, ginger, cinnamon, cardamom…
In India turmeric is used since ancient times to eliminate the toxins from the body, and to treat nausea, vomiting, nematodes, and today there is scientific evidence proving its efficacy in preventing and treating cancer and dementia.

Cloves are amazing in treating infections, and ginger stimulates the blood circulation.

Ingredients:

½ tsp ginger
½ tsp cinnamon
½ tsp cloves
1/6 tsp turmeric
a pinch of cardamom
1 ½ cup of water
1/2 coconut milk
honey, optional

Preparation

Mix all the spices together and add a cup and a half of boiled water.

If you can not find ground spices and you use seeds instead, you should boil the tea and cook it on a low heat for 5 minutes.
Stir well.
Add the warm coconut milk.
Do not strain the tea and drink it during the whole day, and you can drink as much as you like.
This tea will boost your energy and help you cleanse your organism from parasites and toxins, and also treat colds, weak immunity, and various health conditions.
http://worldtruth.tv/this-amazing-oriental-tea-can-cure-more-than-50-health-conditions-and-detox-the-body/

Home made Celery Juice-Video

Celery juice is a drink that the drug companies don’t want you to take on a regular basis. Why? This drink is an all natural very inexpensive way to help maintain your health and in some cases may even help in the prevention of many maladies that the pharmaceuticals just want you to take their very expensive pills that sometimes have very bad side effects. Check out the excerpt from an article that I recently found .  It reveals what the drug companies really want to keep from you…  A healthy all natural drink that delivers a multitude of nutrients and vitamins as well as many amazing wellness remedies. 

Fights Cancer – Celery is known to contain at least eight families of anti-cancer compounds. A study at Rutgers University of New Jersey found that celery contains a number of compounds that help prevent cancer cells from spreading. 

Lowers Cholesterol – Laboratory studies also indicate that butyl phthalide, a chemical in celery, may help reduce LDL (bad) cholesterol. According to researchers at the University of Chicago, celery reduces cholesterol levels by as much as 7 points with as little as 2 stalks a day. Celery also aids in increasing bile acid secretion which helps to remove cholesterol from the body.

Aids in Digestion – Special nutrients in the fiber are released during juicing that aid bowel movements. This makes celery a natural laxative that helps to relieve constipation. It also helps relax nerves that have been overworked by man-made laxatives.

Diuretic – The potassium and sodium in celery juice are powerful body fluid regulators that stimulate urine production to help rid the body of excess fluid.

Lower blood pressure – Celery’s potential for reducing high blood pressure has long been recognized by Chinese medicine. Studies show that drinking celery juice every day for 1 week can significantly help lower blood pressure.

Insomnia – The minerals and essential oils in celery juice have a calming effect on the nervous system, making it beneficial for insomniacs. Its high magnesium levels help people to relax into a soothing and restful sleep.

Elimination and Prevention of stones – Celery juice is an amazing eliminator of toxins from the body, which aids in the breaking and elimination of urinary and gall bladder stones. This lovely juice helps those who have suffered from stones from getting them again.

Increased Sexuality – Celery juice is beneficial for weak sexuality, yet doesn’t cause an uncontrollable urge as some pharmaceutical drugs do. Celery balances the system rather than increasing it.

Celery can be juiced with any other fruits or vegetables. A particularly delicious and powerful combination is carrot, apple, cucumber and celery.

Celery Juicing Video

http://www.letsgoallnatural.com/drug-companies-dont-want-know-celery-juice/

Lemon: The quintessential cancer destroyer and all-around health tonic

By Carolanne Wright



After the excesses of the holiday season, the unassuming lemon can offer much needed relief for an overtaxed body. Jammed packed with nutrients, this upbeat fruit is a cost-effective way to trim down, detoxify and boost vitality. Lemons also conceal a little known health secret - that is, by enjoying the entire fruit (juice, rind, pith and seeds), we can strongly discourage cancer, bone loss, hypertension and more.

Inexpensive gateway to health

Many are familiar with the famous lemon detox diet and have reaped the benefits of the protocol, such as glowing skin, better digestion and a slimmer body. However, few are aware that lemons are also an exceptionally potent treatment for thrush, parasites and calcium stones in the urinary tract.

A study in the International Journal of Phytotherapy and Phytopharmacology found lemon juice was more effective in healing oral thrush in HIV patients than the standard remedy of gentian violet. And researchers at Bakirkoy Research and Training Hospital in Istanbul, Turkey discovered lemons are a viable alternative to potassium citrate in the treatment of urinary calcium stones. Traditionally, lemon peel oil has been used to discourage intestinal parasites, while the vitamin C-rich juice and rind help to increase bone mineral density.

What's more, Dr. Chakravarty, chief science officer and member of the Hope4Cancer executive team, notes that lemons:

Regulate blood pressure
Treat acne
Alleviate depression, stress and anxiety
Possess antibacterial and antiviral properties

Don't trash the peel

Before tossing the lemon peel once the juice has been extracted, consider this: the rind contains up to 10 times the vitamins and bioactive compounds of the juice itself. The peel also impedes tumor proliferation according to a study published in the Journal of Agricultural and Food Chemistry. Likewise, research in the journal of Nutrition and Cancer found a striking reduction of squamous cell carcinoma in those who ingested citrus peel, compared to participants who only consumed the juice. The team believes these findings are due to the concentration of d-limonene oil in citrus fruit rinds - a known inhibitor of breast, lung and colon cancers.

http://www.naturalnews.com/043671_lemon_rind_cancer_cures.html#ixzz36RQC4ZSU